Harvard’s Wyss Institute Develops New Nanodevice Manufacturing Strategy Using Self-Assembling DNA “Building Blocks”

30.05.2012. Video
Novel technology could enable new tools for delivering drugs directly to disease sites in the body.

Researchers at the Wyss Institute have developed a method for building complex nanostructures out of short synthetic strands of DNA. Called single-stranded tiles (SSTs), these interlocking DNA “building blocks,” akin to Legos®, can be programmed to assemble themselves into precisely designed shapes, such as letters and emoticons. Further development of the technology could enable the creation of new nanoscale devices, such as those that deliver drugs directly to disease sites.

The technology, which is described in today’s online issue of Nature, was developed by a research team led by Wyss core faculty member Peng Yin, Ph.D., who is also an Assistant Professor of Systems Biology at Harvard Medical School. Other team members included Wyss Postdoctoral Fellow Bryan Wei, Ph.D., and graduate student Mingjie Dai.

DNA is best known as a keeper of genetic information. But in an emerging field of science known as DNA nanotechnology, it is being explored for use as a material with which to build tiny, programmable structures for diverse applications. To date, most research has focused on the use of a single long biological strand of DNA, which acts as a backbone along which smaller strands bind to its many different segments, to create shapes. This method, called DNA origami, is also being pursued at the Wyss Institute under the leadership of Core Faculty member William Shih, Ph.D. Shih is also an Associate Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and the Department of Cancer Biology at the Dana-Farber Cancer Institute.

In focusing on the use of short strands of synthetic DNA and avoiding the long scaffold strand, Yin’s team developed an alternative building method. Each SST is a single, short strand of DNA. One tile will interlock with another tile, if it has a complementary sequence of DNA. If there are no complementary matches, the blocks do not connect. In this way, a collection of tiles can assemble itself into specific, predetermined shapes through a series of interlocking local connections.

In demonstrating the method, the researchers created just over one hundred different designs, including Chinese characters, numbers, and fonts, using hundreds of tiles for a single structure of 100 nanometers (billionths of a meter) in size. The approach is simple, robust, and versatile.

As synthetically based materials, the SSTs could have some important applications in medicine. SSTs could organize themselves into drug-delivery machines that maintain their structural integrity until they reach specific cell targets, and because they are synthetic, can be made highly biocompatible.

“Use of DNA nanotechnology to create programmable nanodevices is an important focus at the Wyss Institute, because we believe so strongly in its potential to produce a paradigm-shifting approach to development of new diagnostics and therapeutics,” said Wyss Founding Director, Donald Ingber, M.D., Ph.D.

 

Source: http://wyss.harvard.edu/viewpressrelease/84/

Zanimljivosti

06.12.2017. Zanimljivosti
Potential weapons for the battle against antibiotic resistance discovered

The bacterium Pseudomonas aeruginosa can produce specific molecular factors that dramatically increase or decrease an antibiotic's ability to kill Staphylococcus aureus, another bacterium that often co-infects with P. aeruginosa. The findings point to the possibility of new antibiotics employing these factors to enhance antibiotic susceptibility.


01.08.2017. Zanimljivosti
Walnuts may promote health by changing gut bacteria

A new study has found that walnuts in the diet change the makeup of bacteria in the gut, which suggests a new way walnuts may contribute to better health.


Izdavaštvo

Moćni mikrobi – prikaz knjige Mighty Microbes – The Amazing World of Microorganisms

Skupina znanstvenika i popularizatora znanosti iz Nizozemske se s ovom idejom pozabavila kroz fundaciju Microcanoni, nizozemsku inačicu projekta naziva „Što doista trebate znati o mikrobiologiji“ još 2011. Ta verzija prezentirana je i u amsterdamskom muzeju Artis Micropia, a djelo na engleskome čiji vam prikaz donosim je korak dalje koji je ova skupina ljudi poduzela u ulozi urednika knjige s naslovom Mighty Microbes i podnsalovom The Amazing World of Microorganisms. Osmislili su građu podijeljenu u devet tematskih cjelina, a unutar svake je pet do deset poglavlja (tema) za koje su kao autore ili suautore odabrali znanstvenike koji su sudjelovali u ključnim otkrićima ili su istaknuti stručnjaci u tom području.

Naruči Više


Priručnik za vježbe iz opće mikrobiologije

Ovaj sveučilišni priručnik napisalo je petnaestak autora iz desetak visokoškolskih ustanova iz Zagreba i Rijeke, a sadržaj je podijeljen u petnaest, slikama bogato ilustriranih poglavlja u kojima su opisane i obrađene različite bakteriološke, virološke, mikološke, imunološke i molekularno-biološke metode koje se upotrebljavaju u općoj mikrobiologiji koja se studira na nizu različitih fakulteta i visokih škola.

Naruči Više


Postani član HMD-a

Cilj Društva je okupljanje mikrobiologa i stručnjaka srodnih struka s ciljem unapređenja svih grana mikrobiologije.

Postani član

Šaljite nam novosti

Novosti i zanimljivosti nam šaljite na urednik@hmd-cms.hr.

Skupovi HMD-a

Power of Viruses

Date: May 16-18, 2018

Venue: Poreč, Croatia

It is with great pleasure that we invite you to attend the conference Power of Viruses in Valamar Diamant Hotel, Poreč, Croatia, during May 16-18, 2018.

Posjeti web stranicu


CESAR 2018

Date: 19-22 September 2018

Venue: Sveti Martin na Muri, Croatia

It is our great pleasure to invite you to the 6th Central European Symposium on Antimicrobials and Antimicrobial Resistance, CESAR2018.

Posjeti web stranicu


Arhiva skupova