New tool to distinguish between viral, bacterial infections

01.08.2017. Zanimljivosti

Scientists from the University’s National Institutes of Health-funded Respiratory Pathogens Research Center identified 11 genetic markers in blood that accurately distinguished between viral and bacterial infections (antibiotics help us fight bacterial infections, but aren’t effective and shouldn’t be used to treat viruses). The finding, published in the journal Scientific Reports, is important because physicians don’t have a good way to confirm bacterial infections like pneumonia and more-often-than-not default to an antibiotic.

“It’s extremely difficult to interpret what’s causing a respiratory tract infection, especially in very ill patients who come to the hospital with a high fever, cough, shortness of breath and other concerning symptoms,” said Ann R. Falsey, M.D., lead study author, professor and interim chief of the Infectious Diseases Division at UR Medicine’s Strong Memorial Hospital. “My goal is to develop a tool that physicians can use to rule out a bacterial infection with enough certainty that they are comfortable, and their patients are comfortable, foregoing an antibiotic.”

A group of 94 adults hospitalized with lower respiratory tract infections were recruited to participate in Falsey’s study. The team gathered clinical data, took blood from each patient, and conducted a battery of microbiologic tests to determine which individuals had a bacterial infection (41 patients) and which had a non-bacterial or viral infection (53 patients). Thomas J. Mariani, Ph.D., professor of Pediatrics and Biomedical Genetics at URMC, used complex genetic and statistical analysis to pinpoint markers in the blood that correctly classified the patients with bacterial infections 80 to 90 percent of the time.

“Our genes react differently to a virus than they do to bacteria,” said Mariani, a member of the Respiratory Pathogens Research Center (RPRC). “Rather than trying to detect the specific organism that’s making an individual sick, we’re using genetic data to help us determine what’s affecting the patient and when an antibiotic is appropriate or not.”

Read more here.

Zanimljivosti

16.06.2018. Zanimljivosti
For The First Time, Scientists Have Caught Bacteria “Fishing” For DNA From Their Dead Friends
Bacteria are slippery little suckers. They evolve rapidly, developing resistance to antibiotics and therefore becoming increasingly difficult to deal with. Now, for the first time, researchers have caught on film one of the mechanisms the microbes use for this speedy evolution.
18.04.2018. Zanimljivosti
Odilorhabdins: Researchers Discover New Class of Antibiotics

An international team of scientists led by the University of Illinois, Chicago, has discovered a new class of naturally produced, ribosome-targeting antibacterial agents, odilorhabdins, produced by a nematode-symbiotic bacterium.


Izdavaštvo

Moćni mikrobi – prikaz knjige Mighty Microbes – The Amazing World of Microorganisms

Skupina znanstvenika i popularizatora znanosti iz Nizozemske se s ovom idejom pozabavila kroz fundaciju Microcanoni, nizozemsku inačicu projekta naziva „Što doista trebate znati o mikrobiologiji“ još 2011. Ta verzija prezentirana je i u amsterdamskom muzeju Artis Micropia, a djelo na engleskome čiji vam prikaz donosim je korak dalje koji je ova skupina ljudi poduzela u ulozi urednika knjige s naslovom Mighty Microbes i podnsalovom The Amazing World of Microorganisms. Osmislili su građu podijeljenu u devet tematskih cjelina, a unutar svake je pet do deset poglavlja (tema) za koje su kao autore ili suautore odabrali znanstvenike koji su sudjelovali u ključnim otkrićima ili su istaknuti stručnjaci u tom području.

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Priručnik za vježbe iz opće mikrobiologije

Ovaj sveučilišni priručnik napisalo je petnaestak autora iz desetak visokoškolskih ustanova iz Zagreba i Rijeke, a sadržaj je podijeljen u petnaest, slikama bogato ilustriranih poglavlja u kojima su opisane i obrađene različite bakteriološke, virološke, mikološke, imunološke i molekularno-biološke metode koje se upotrebljavaju u općoj mikrobiologiji koja se studira na nizu različitih fakulteta i visokih škola.

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Cilj Društva je okupljanje mikrobiologa i stručnjaka srodnih struka s ciljem unapređenja svih grana mikrobiologije.

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