Poziv na predavanje – dr. sc. D. A. Hopwood: Streptomyces Genomics: New Routes to Antibiotic Discovery, Zagreb, 18.5.2011.

12.05.2011. Novosti

Zavod za molekularnu biologiju IRB i Bakteriološka sekcija HMD, organiziraju predavanje:

18.05.2011. u 13 h / I krilo IRB

Streptomyces Genomics: New Routes to Antibiotic Discovery

David A. Hopwood, John Innes Centre, Norwich, UK

 Most natural antibiotics are made by the actinomycetes, a group of Gram-positive, mvcelial bacteria that includes the genera Streptomyces and its relatives. After the “Golden Age” of antibiotic discovery in the 1960s, very few new antibiotics were discovered, but the need for novel compounds increased, with the rise of such dangerous pathogens as methicillin resistant Staphyloccus aureus (MRSA), vancomycin resistant Enterococcus faecalis (VRE) and multiply drug resistant (MDR) Mycobacterium tuberculosis. In the 1990s, pharmaceutical companies turned to combinatorial chemistry to generate large libraries of compounds, but this approach to antibiotic discovery was unsuccessful because the compounds did not react with biological targets in the way that natural metabolites have been selected to do over millions of years of evolution. More recently, advances in Streptomyces genetics made possible the generation of novel, “hybrid” antibiotics by genetic engineering. More promising is the discovery from actinomycete genomics that the organisms have the potential to make many more interesting compounds than are revealed by classical screening campaigns. The current challenge is to find ways to wake up the “sleeping” gene clusters so as to make available a whole gamut of novel metabolites for assessment as antibiotics. Examples of promising strategies aimed at this objective will be discussed.

Projekt "U Društvu mikroba"

Osnovna svrha projekta je doprinijeti uvođenju, razvoju i održivosti programa društveno korisnog učenja na fakultetima. Više o projektu

Projekt je sufinancirala Europska unija iz Europskog socijalnog fonda
Zanimljivosti

13.09.2018. Zanimljivosti
Probiotics are mostly useless and can actually hurt you
Probiotics are living micro-organisms that are taken by millions of people to boost their microbiome or to restore their gut ecosystem after a dose of antibiotics. Yet questions remain about whether they actually work.
16.08.2018. Zanimljivosti
The urinary microbiome associated with bladder cancer
An international group of scientists led by dr. Terzić, including Croatian microbiological society member dr. Viljemka Bučević Popović as a first author, have recently published a paper on the association of urinary microbiome and bladder cancer.
Postani član HMD-a

Cilj Društva je okupljanje mikrobiologa i stručnjaka srodnih struka s ciljem unapređenja svih grana mikrobiologije.

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